Fig. 6.

Neuronal eIF2α(P) transiently increases after injury. In a sham-injured animal, low basal levels of eIF2α(P) are observed in the mediodorsal neocortex (A). Four hours after injury, scattered neurons intensely staining for eIF2α(P) can be observed in lamina V of the mediodorsal neocortex (B). Many neurons in comparable regions exhibit elevated immunoreactivity for eIF2α(P) 24 hr after injury (C). At 7 d after injury, eIF2α(P) immunoreactivity returns to levels similar to controls (D). Scale bars, 100 μm.