Fig. 10.

The PKC inhibitor Bis attenuates LTP. Open circles are ensemble averages from control LTP experiments. Filled circles are ensemble averages from slices given LTP-inducing HFS with 500 nm Bis in the perfusing solution (indicated by the bar). Responses recorded from slices given LTP-inducing HFS in the presence of Bis were compared with responses recorded from a control slice from the same animal (in an adjacent recording chamber) that received HFS in the absence of the inhibitor. Error bars are SEM for six determinations. When we compared the fEPSP slope 45 min after HFS with the fEPSP slope immediately before HFS, small but statistically significant potentiation was observed in the presence of Bis (p < 0.05 by paired Student'st test).