Fig. 3.

Organization and lineage in the SVZ.Left, Cross section of the anterior rodent brain indicating the location of the SVZ on the lateral wall of the LV. On the right is the cellular composition and organization of the SVZ. Chains of young neurons (A cells, red) are surrounded by B cells (blue) that have astrocytic characteristics and form tube-like structures. Clusters of highly proliferative C cells are associated with the chains of A cells. Ependymal (E) cells form an epithelial layer that separates the SVZ from the ventricle (LV). B cells generate transient amplifying C cells that generate the A cells (top). Bottom left, BMPs inhibit neurogenesis and favor glial differentiation (blue). Noggin secreted by ependymal cells binds BMPs and releases some B cells to become neurogenic and produce C (green) and A (red) cells.