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. 2002 Feb 1;22(3):1146–1154. doi: 10.1523/JNEUROSCI.22-03-01146.2002

Fig. 3.

Fig. 3.

THC place preference and aversion. A, Place preference to THC is abolished in MOR −/− mice, whereas place aversion is diminished (number of mice per group from 13 to 14);B, DOR −/− mice show similar place conditioning to THC than their wild-type controls (number of mice per group from 10 to 13); and C, Place aversion to THC is abolished in KOR −/− mice (number of mice per group from 11 to 12) mice. THC1 (1 mg/kg, i.p.); THC5 (5 mg/kg, i.p.). Mice conditioned to the dose of 1 mg/kg THC received a previous THC injection (1 mg/kg, i.p.) in their home cage, 24 hr before the start of the conditioning phase. In wild-type mice, THC1 conditions reveal THC place preference, whereas THC5 conditions show THC place aversion. Values are expressed as mean ± SEM. Scores were calculated as the difference between test and preconditioning time spent in the drug-paired compartment. ★p < 0.05, ★★p < 0.01, comparison between treatments; ⋆⋆p < 0.01, comparison between genotypes (one-way ANOVAs).