Table 3.
One-way ANOVA of place conditioning scores to THC of mice lacking μ-, δ-, or κ-opioid receptor
| Group | Comparison | MOR | DOR | KOR | |||
|---|---|---|---|---|---|---|---|
| F | p | F | p | F | p | ||
| Vehicle | +/+ vs −/− | F(1,27) = 0.003 | p = 0.955 | F(1,18) = 0.473 | p = 0.501 | F(1,19) = 0.017 | p = 0.898 |
| THC1 | +/+ vs −/− | F(1,26) = 12.76 | p < 0.001 | F(1,24) = 2.705 | p = 0.114 | F(1,22) = 0.046 | p = 0.833 |
| THC5 | +/+ vs −/− | F(1,25) = 2.292 | p = 0.143 | F(1,25) = 0.131 | p = 0.721 | F(1,21) = 9.995 | p < 0.01 |
| +/+ | THC1 vs VEHICLE | F(1,26) = 8.953 | p < 0.01 | F(1,21) = 4.088 | p < 0.05 | F(1,22) = 8.041 | p < 0.05 |
| +/+ | THC5 vs VEHICLE | F(1,26) = 5.752 | p < 0.05 | F(1,21) = 7.785 | p < 0.05 | F(1,23) = 9.704 | p < 0.01 |
| −/− | THC1 vs VEHICLE | F(1,27) = 0.124 | p = 0.727 | F(1,21) = 14.437 | p < 0.001 | F(1,21) = 7.165 | p = 0.05 |
| −/− | THC5 vs VEHICLE | F(1,26) = 0.914 | p = 0.348 | F(1,22) = 1.952 | p = 0.177 | F(1,20) = 0.13 | p = 0.910 |
One-way ANOVA with treatment or genotype as between-subjects factors. See Materials and Methods for details. Significant effects of genotype are observed in the MOR strain at 1 mg/kg THC and in the KOR strain at 5 mg/kg THC. The significant effect of treatment observed in MOR +/+ mice is absent in MOR −/− mice with 1 mg/kg THC. The significant effect of treatment observed in KOR +/+ mice is absent in KOR −/− mice with 5 mg/kg THC.