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CDT2 activates CDKs through downregulating CDKs inhibitor P21. (A and B) Overexpression of CDT2 dramatically reduced P21 in HEK293 cells compared with controls. (C) Overexpression of CDT2 significantly increased the activities of CDK1, CDK2, CDK3, CDK4, and CDK5 compared with controls. All data represent mean ± standard error of the mean. ** P < .01; *** P < .001, versus vector control.
