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. Author manuscript; available in PMC: 2019 Sep 24.
Published in final edited form as: Alzheimers Dement. 2018 Oct 12;15(2):217–231. doi: 10.1016/j.jalz.2018.08.013

Fig. 3.

Fig. 3.

RNA-seq data from DTL overexpression experiments in HEK293 cells confirmed upregulation of several CDKs and further identified six AD GWAS risk genes as targets of DTL. (A) Differential expression of several CDK genes. (B) Differential expression of six AD GWAS susceptibility genes. (C) Functional pathways most enriched in the gene signatures upregulated (red bars) and downregulated (blue bars) by DTL overexpression. P value significance is calculated from a one-tailed t-test. ** P < .01; *** P < .001; **** P < .0001; ***** p < .00001. Abbreviations: AD, Alzheimer’s disease; APOE, apolipoprotein E; OE, overexpression.