Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 17;10:1045. doi: 10.3389/fphar.2019.01045

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Ohno, Kunisawa and Shimizu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mechanisms underlying serotonergic modulation of antipsychotic-induced extrapyramidal side effects (EPS). Activation of 5-HT_1A receptors, especially postsynaptic 5-HT_1A receptors in the striatum and cerebral cortex, alleviates antipsychotic-induced EPS. Blockade of 5-HT₂ receptors on nigral dopamine neurons and their nerve terminals in the striatum can relieve the negative serotonergic regulation and thereby can increase the dopaminergic activities, which contributes to EPS reduction. Similarly, blockade of 5-HT₃ and 5-HT₆ receptors attenuates antipsychotic-induced EPS possibly via acting in the striatum. This figure is quoted and arranged from Biol. Pharm. Bull. 36, 1396, 2013.