Figure 7.

Interactions between antidepressants and antipsychotics in induction of extrapyramidal side effects (EPS). Bradykinesia was estimated by the pole test as described in Figure 6 legend. Although low dose (0.3 mg/kg) of haloperidol showed only weak effects in the pole test, combined treatment with selective serotonin reuptake inhibitors, fluoxetine and paroxetine, markedly potentiated haloperidol-induced bradykinesia in a synergistic manner. By contrast, the tetracyclic antidepressant mirtazapine, which possesses α₂, 5-HT₂ and 5-HT₃ antagonistic actions, reduced bradykinesia induced by a moderate dose (0.5 mg/kg) of haloperidol. *P<0.05, **P,0.01; Significantly different from the control values. This figure is quoted and arranged from Prog. Neuro-Psychopharmacol. Biol. Psychiatry 38, 252, 2012.