Table 2.

In vitro β-CA (Cab [31], scCA [31–34], CgCA [34], MgCA [32], VchCAβ [35], mtCA 3 [36], BsuCA1 [37], FtuCA [37], LdcCA [38, 39], and EhiCA [38]) activation data with amines and amino acids (1–19).

		KA (µM)a
No	Compound	Cab	scCA	CgCA	MgCA	VchCAβ	mtCA 3	BsuCA1	FtuCA	LdcCA	EhiCA
1	L-His	69	82	37	29.3	20.3	18.2	1.76	40.7	8.21	78.7
2	D-His	57	85	21.2	18.1	18.0	32.5	12.3	78.3	4.13	9.83
3	L-Phe	70	86	24.1	34.1	15.4	30.6	1.16	69.1	9.16	16.5
4	D-Phe	10.3	86	15.7	10.7	5.12	44.1	1.21	75.0	3.95	10.1
5	L-DOPA	11.4	90	23.3	8.31	8.36	30.0	2.07	>100	1.64	16.6
6	D-DOPA	15.6	89	15.1	13.7	6.27	9.74	2.34	44.8	5.47	4.05
7	L-Trp	16.9	91	22.8	10.1	4.18	8.98	1.25	34.1	4.02	5.24
8	D-Trp	41	90	12.1	12.5	5.89	43.7	13.7	30.5	6.18	4.95
9	L-Tyr	10.5	85	9.5	15.7	6.15	28.9	1.38	>100	8.05	4.52
10	D-Tyr	19.2	84	7.1	25.1	0.94	17.6	0.95	>100	1.27	1.07
11	4-H2N-L-Phe	89	21.3	31.6	13.4	7.21	40.5	1.18	>100	15.9	8.12
12	Histamine	76	20.4	27.4	10.9	9.50	34.2	3.71	>100	0.74	7.38
13	Dopamine	51	13.1	27.6	9.43	1.24	12.1	1.54	>100	0.81	30.8
14	Serotonin	62	15.0	16.7	14.2	1.37	10.3	4.26	>100	0.62	4.94
15	2-Pyridyl-methylamine	18.7	16.2	15.0	6.12	0.18	43.3	1.62	46.3	0.23	>100
16	2–(2-Aminoethyl)pyridine	40	11.2	16.3	7.30	1.00	45.9	5.20	>100	0.012	>100
17	1–(2-Aminoethyl)-piperazine	13.8	9.3	14.9	0.81	0.24	50.3	43.1	51.8	0.009	43.8
18	4–(2-Aminoethyl)morpholine	18.5	10.2	10.1	5.82	12.8	52.0	9.56	>100	0.94	>100
19	L-Adrenaline	11.5	0.95	10.8	0.72	8.73	52.2	0.70	>100	4.89	25.6

^aMean from 3 different determinations (errors in the range of 5–10% of the reported values, data not shown).