Table 3.

In vitro γ-CA (Zn-Cam [31], Co-Cam [31], BpsγCA [40], PhaCA [41], and CpsCA [41]), δ-CA (TweCAδ) [42], ζ-CA (ZnTweCAζ) [43], and η-CA (PfaCA) [44] activation data with amines and amino acids (1–19).

		KA (µM)a
No	Compound	Zn-Cam	Co-Cam	BpsγCA	PhaCA	CpsCA	TweCAδ	ZnTweCAζ	PfaCA
1	L-His	68	135	24.7	12.6	47.5	0.75	0.81	1.06
2	D-His	46	73	0.086	9.41	35.9	4.90	7.16	2.19
3	L-Phe	68	70	1.73	15.8	>100	2.15	15.4	0.43
4	D-Phe	42	24	0.13	3.19	15.4	1.96	9.63	0.75
5	L-DOPA	39	38	0.072	1.08	4.79	2.11	3.19	0.12
6	D-DOPA	37	41	0.98	0.72	11.2	6.24	2.87	0.39
7	L-Trp	38	47	0.43	7.12	21.3	0.93	8.54	5.21
8	D-Trp	33	68	0.052	13.9	36.8	0.69	1.79	8.47
9	L-Tyr	24	53	0.20	1.02	19.5	1.52	0.98	1.02
10	D-Tyr	–	–	32.8	7.35	18.4	0.051	0.62	8.55
11	4-H2N-L-Phe	72	22	0.009	3.27	17.2	18.9	7.90	1.00
12	Histamine	63	9.2	0.12	6.48	20.6	1.34	1.27	9.86
13	Dopamine	54	18.4	0.014	8.70	32.1	0.51	10.1	9.97
14	Serotonin	38	0.97	0.10	9.05	34.8	0.90	3.06	7.18
15	2-Pyridyl-methylamine	11.4	8.7	2.36	2.39	21.5	5.28	0.88	3.69
16	2–(2-Aminoethyl)pyridine	24	18.5	0.034	18.7	38.2	8.16	0.85	6.75
17	1–(2-Aminoethyl)-piperazine	10.1	16.1	0.018	15.1	33.0	4.37	0.12	0.71
18	4–(2-Aminoethyl)morpholine	45	38	0.015	10.1	34.2	7.39	0.15	5.33
19	L-Adrenaline	39	8.9	0.019	17.5	79.8	2.43	0.092	2.40

^aMean from 3 different determinations (errors in the range of 5–10% of the reported values, data not shown).