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Cerebral amyloidosis in the neocortex of APP23 transgenic mice. A, In 8-month-old mice only few Aβ-immunostained amyloid deposits were found (arrows).B, In contrast, 27-month-old APP23 mice exhibited severe cerebral amyloidosis throughout the neocortex. The total amyloid load in the neocortex of the mouse shown was estimated to be 25.7%. Scale bar, 150 μm. A and B have the same magnification.
