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Increase in BrdU-positive cells in the neocortex of aged APP23 mice. Total BrdU-positive cells in the neocortex of young (4-month-old) and aged (24-month-old) wild-type and APP23 mice. Numbers are for one hemisphere only. Note the approximately fourfold increase in BrdU-labeled cells in the aged APP23 mice compared with all three other groups (*p values < 0.001).
