Fig. 2.

Effects of cocaine on [³H]DA uptake in synaptosomes obtained from FCx, Acb, and caudate from DAT knock-out (DAT-KO) (A), NET knock-out (NET-KO) (B), and wild-type (WT) mice. The rate of [³H]DA uptake at each concentration of cocaine is expressed as a percentage of that observed for each genotype with only the vehicle present in the assay. Values represent mean ± SEM obtained from three or four independent experiments using fresh tissue pooled from five or six mice each time.