Table 1.
Clinical ratings at baseline and after focal muscimol injections in GPi and STN in two parkinsonian monkeys
Nucleus | Monkey | Injection | Site | Generalized akinesia (0–5) | Generalized bradykinesia (0–4) | Contralateral forelimb akinesia (0–5) | Contralateral circling (0–4) | Atypical behavior (0–3) | Dyskinesias (0–3) |
---|---|---|---|---|---|---|---|---|---|
GPi | D | Baseline1-a | 3.2 | 2.8 | 4.9 | 0 | 0 | 0 | |
Muscimol | L7caudal | 2* | 3 | 5 | 1* | 2* | 0 | ||
L9dorsal | 3 | 3 | 4 | 0 | 0 | 0 | |||
L9central | 1* | 1* | 1* | 0 | 0 | 0 | |||
L9rostral | 3 | 3 | 5 | 0 | 0 | 0 | |||
L11dorsal | 2* | 3 | 3* | 0 | 0 | 0 | |||
L11central | 3 | 3 | 5 | 0 | 0 | 0 | |||
Z | Baseline | 3.4 | 3.3 | 4.9 | 1.2 | 0 | 0 | ||
Muscimol | L6caudal | 2* | 2* | 4 | 4* | 0 | 0 | ||
L9central | 3 | 3 | 4 | 3 | 0 | 0 | |||
L8caudal | 3 | 3 | 5 | 3 | 0 | 0 | |||
L8central | 1* | 2* | 3* | 2 | 0 | 0 | |||
L8rostral | 3 | 2* | 4 | 0 | 0 | 0 | |||
L10dorsal | 3 | 3 | 4 | 1 | 0 | 0 | |||
L10caudal | 3 | 3 | 4 | 2 | 0 | 0 | |||
L10rostral | 3 | 3 | 5 | 3 | 0 | 0 | |||
STN | D | Baseline | 2.8 | 1.0 | 4.8 | 0 | 0 | 0 | |
Muscimol | L6dorsal | 2 | 1 | 5 | 0 | 0 | 0 | ||
L7dorsal | 1* | 1 | 3* | 0 | 0 | 0 | |||
L7ventral | 2 | 1 | 5 | 0 | 0 | 0 | |||
L8central | 0* | 1 | 2* | 1* | 0 | 1* | |||
Z | Baseline | 1.9 | 2.4 | 4.7 | 2.3 | 0 | 0 | ||
Muscimol | L5dorsal | 2 | 3 | 5 | 4* | 0 | 0 | ||
L5ventral | 2 | 2 | 5 | 2 | 2* | 0 | |||
L6dorsal | 2 | 2 | 5 | 3 | 0 | 0 | |||
L6ventral | 2 | 3 | 5 | 2 | 0 | 0 | |||
L7dorsal | 2 | 2 | 3* | 2 | 0 | 1* | |||
L7ventral | 3 | 2 | 5 | 2 | 1* | 0 |
Mean scores across multiple baseline observations (minimum number of observations;n = 6).
Indicates postinjection scores that differ from all corresponding baseline scores.