Figure 3.

Cartilage persistence of conventional HA and thermosensitive HA Nano 1 conjugated with cyanine 5. In vivo imaging system showed the retention of HA and HA Nano 1 after (A, B) intra-articular injection in an OA mouse model and (C, D) subcutaneous injection in healthy mice (n = 4). (E) Fluorescence micrographs of right knee 2 months after OA induction (F: femur, T: tibia, scale bar = 300 µm). (F) Fluorescence micrographs of the skin at 21 days after injection (D: Dermis, scale bar = 500 µm), and mice received an injection of PBS as the sham group. Reprinted with permission from Maudens et al. (2018).