Curcumin |
PLGA |
100–200 nm |
Mono-iodoacetate-induced osteoarthritis in rats |
Nanocurcumin prevented the articular cartilage changes |
Niazvand et al. (2017) |
KGN |
Chitosan nanoparticles |
150 ± 39nm |
ACLT OA rat |
Sustained release of kartogenin and less degenerative changes compared with free KGN |
Kang et al. (2014) |
KGN |
Pluronic-chitosan nanoparticle |
395 nm |
ACLT and DMM OA rat model |
Suppressed the progression of OA in treated rats, further decreased with cold treatment |
Kang et al. (2016) |
KAFAK |
PEGylated Poly(NIPAM) |
200–500 nm |
Ex vivo inflammatory of bovine cartilage plugs |
Decrease IL-6 production |
McMasters et al. (2017) |
KAFAK |
Poly(NIPAm-AMPS) |
100–400 nm |
IL-1β stimulated inflammationexvivo
|
Reduce the production of IL-6 |
Bartlett et al. (2013) |
Texas Red(dye) |
Avidin |
7 nm |
Health rat |
Penetrate the full articular cartilage within 6 h, and stay up to 7 days |
Bajpayee et al. (2014) |
Dexamethasone |
Avidin, PEG |
Not reported |
Cytokine-induced catabolism |
Avidin-DEX conjugates had the most remarkable bioactivity |
Bajpayee et al. (2016) |
Diacerein |
ChS modified SLN |
300–500 nm |
Sodium iodoacetate induced osteoarthritis rat model |
Increased chondrocyte regeneration |
Jain et al. (2014) |
FITC |
PCL-PEO and dextran |
∼100 nm |
Health rat |
70% of the NPs retained in the joint for 1 week |
Morgen et al. (2013) |
Dexamethasone |
Avidin |
Not reported |
Anterior cruciate ligament transection in rabbits |
Highly reduced joint inflammation by ∼49% |
Bajpayee et al. (2017) |
Interleukin-1 receptor antagonist |
Self-assembling nanoparticles with block copolymer |
270± 5 nm |
In vitro rabbit synoviocytes In vivo healthy rat |
increased whole joint retention of IL-1Ra |
Whitmire et al. (2012) |
GFP-mASOs |
PEGylated carbon nanotube |
20 × 100 nm |
DMM OA model |
Enhanced retention up to 14 days |
Sacchetti et al. (2014) |
Near infrared dye |
HA-coated Albumin nanoparticles |
108.1± 5.9nm |
In vitro chondrocytes |
Improved chondrocyte uptake of the loaded drug |
Chen et al. (2013) |