. 2019 Jul 29;12(4):460–475. doi: 10.1159/000501319

Table 2.

Changes in anthropometrics, ambulatory blood pressure, and resting heart rate under metreleptin substitution

Patients	Anthropometrics									Ambulatory blood pressure, mm Hg						Resting heart rate
	weight, kg			BMI, kg/m²			BMI z-score			average systolic BP			average diastolic BP			average heart rate, bpm
	0	1st	7–14	0	1st	7–14	0	1st	7–14	0	1st	7–14	0	1st	7–14	0	1st	7–14
	weeks	week	months	weeks	week	months	weeks	week	months	weeks	week	months	weeks	week	months	weeks	weeks	months
Patient 1	103.4	101.2	80.5	35.7	34.6	26.6	3.0	2.9	1.7	106.5			70.5			79.0	89.5	80.5
Patient 2	146	144	123	53.0	52.5	44.6	4.7	4.7	4.2	116.7	120.8	128.7	76.9	79.4	91.1^a	79.5	82.0	71.0
Patient 3	65.5	64.3	63.8	31.9	31.4	28.4	2.6	2.6	2.2	140.5^a	126.4	137.0	93.5^a	83.5	87.1	93.6	101.7	82.6
Patient 4	53	52.3	40.2	27.0	26.7	19.5	2.3	2.3	0.5	134.9^a	141.1^a	111.1	95.9^a	105.5^a	73.2	100.6	107.5	88.5
Patient 5	50.7	51.3	39.9	35.4	35.8	25.3	4.1	4.1	3.0	129.0^a		149.0^a	83.9^a		103.0^a	88.9	115.0	84.7
Patient 6	77	78.1	72.5	39.3	39.9	34.3	3.5	3.5	3.1	134.1^a	147.0^a		89.2^a	110.2^a		83.9	103.8	83.0

Mean ± SD	82.6±	81.9±	70.2 ±	37.1±	36.8±	29 .8 ±	3.4±	3.4±	2 .5 ±	127.0±	133.8±	131.4±	85.0±	94.6±	88.6±	87.6±	99 .9 ±	81.7±
	33.3	32.6	28 .2 ^*	8.1	8.1	7 .9 ^*	0.8	0.8	1 .2 ^*	11.7	10.6	13.8	9.0	13.4	10.7	7.7	11 .0 ^*	5.4

BP, blood pressure; SD, standard deviation.

< 0.05 compared to baseline (bold type).

Blood pressure above the 95th percentile for height and gender indicating hypertension.