Table 3.

Changes in Schellong and cold pressor test results under metreleptin substitution

Patients	Schellong test									Cold pressor test
	average heart rate, bpm			average systolic BP, mm Hg			max. drop in systolic BP, mm Hg			systolic BP response, mm Hg			diastolic BP response, mm Hg			max. heart rate, bpm
	0	1st	7–14	0	1st	7–14	0	1st	7–14	0	1st	7–14	0	1st	7–14	0	1st	7–14
	weeks	weeks	months	weeks	week	months	weeks	week	months	weeks	week	months	weeks	week	months	weeks	week	months
Patient 1	86.0	102.0	109.0	89.0	95.0	102.0	1.0	12.0	1.0	2.0	6.0	1.0	5.0	10.0	14.0	103.0	114.0	88.0
Patient 2	102.4	104.0	95.5	110.0	116.2	115.8	−37.0	−16.0	−20.0	5.0	6.0	18.0	6.5	−3.0	−1.5	73.0	76.0	74.0
Patient 3	125.5	131.6	103.9	109.5	112.3	96.3	−20.0	−4.0	−10.0	0.5	13.0	11.0	6.5	19.0	13.5	109.0	125.0	84.0
Patient 4	114.7	123.3	109.6	100.4	92.9	111.0	−26.0	−36.0	−19.0	−6.0	−2.0	13.0	1.0	16.0	3.0	86.0	125.0	94.0
Patient 5	91.4	124.7	92.6	117.8	100.6	110.1	−22.0	−33.0	−17.0	12.5	−5.5	−2.5	44.5	9.0	7.0	119.0	114.0	102.0
Patient 6	97.3	108.2		95.9	110.3		−24.0	−26.0		20.0	25.5	−7.0	48.0	36.0	−10.0	88.0	90.0	100.0
Mean ± SD	102.9±	115.6±	102.1±	103.8±	104.5±	107.0±	−21.3±	−17.2±	−13.0±	5.7±	7.2±	5.6±	18.6±	14.5±	4.3±	96.3±	107.3±	90.3±
	13.5	11.3	6.9	9.7	8.9	7.0	11.4	16.9	7.8	8.5	10.1	9.0	19.7	11.8	8.4	15.5	18.2	9.6

BP, blood pressure; SD, standard deviation.