Skip to main content
. 2002 Dec 1;22(23):10313–10323. doi: 10.1523/JNEUROSCI.22-23-10313.2002

Fig. 5.

Fig. 5.

Thalamocortical projections, traced with DiI, show similar ingrowth patterns in WT (A, C,E) and KO (B, D,F) brains at E18.5. A–D, Double-exposure photomicrographs of coronal sections showing the DiI-labeled axons (red) and bisbenzimide counterstaining (blue) in the left hemisphere. Thalamic axons exhibited similar fasciculation patterns in the internal capsule (ic) and cortex (ctx) of WT (+/+) and KO (−/−) brains. In both genotypes, axons had started quite substantially to invade the cortical plate (C,D, arrows). E,F, Confocal microscopic reconstructions revealed similar patterns of invasion in the two genotypes. Thalamic projections extended up to the upper third of the cortical plate and began to show branch formation (arrows). Scale bars: A,B, 300 μm; C, D, 200 μm; E, F, 100 μm. dt, Dorsal thalamus; sp, subplate; liz, lower intermediate zone; mz, marginal zone.