Table 1.
Histological analysis after TBI
| PDAPP:E3 | PDAPP:E4 | PDAPP:E−/− | p < 0.05 | |
|---|---|---|---|---|
| Sample size | 10 | 9 | 4 | |
| Percentage of cortical loss | 24.9 | 21.4 | 21.9 | No |
| Percentage of hippocampal loss | 9.2 | 9.3 | 8.5 | No |
| Percentage of CA3 inferior blade neuron loss | 35.7 | 30.0 | 26.6 | No |
| Percentage of group with Aβ-IR deposits | 20 | 55.6 | 75 | No |
| Percentage of group with molecular layer Aβ-IR deposits | 0 | 44.4 | 0 | Yes |
| Contralateral to TBI: hippocampal Aβ load (%) | 0.1 | 0.9 | 13.8 | Yes |
| Ipsilateral to TBI: hippocampal Aβ load (%) | 0.1 | 2.3 | 10.3 | Yes |
| Contralateral to TBI: % of total Aβ in molecular layer | 0 | 28.1 | 0 | Yes |
| Ipsilateral to TBI: % of total Aβ in molecular layer | 0 | 29.8 | 0 | Yes |