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. 2002 Jun 1;22(11):4346–4356. doi: 10.1523/JNEUROSCI.22-11-04346.2002

Fig. 2.

Fig. 2.

Characterization of pharmacological mGlu2/3-induced LTD. A, Summarized data showing that application of LY354740 (200 nm) resulted in an initial depression, which was followed during washout by an LTD.Inset shows traces (average of 10 consecutive fEPSPs) taken at the points indicated in a typical experiment. Calibration: 0.3 mV, 10 msec. B, Typical whole-cell experiment showing LTD induced by LY354740. Inset shows traces (average of 10 consecutive eEPSCs) taken at points indicated on the graph. Calibration: 100 pA, 25 msec. C, Inhibition of eEPSC 30 min after LY354740 is accompanied by an increase in the paired-pulse ratio. D, In presence of the group 2 mGlu antagonist LY341495 (200 nm), the initial depression induced by LY354740 was reduced and the LTD was prevented. E, Application of LY341495 (200 nm) 60 min after LTD induced by LY354740 did not reverse the LTD. F, Dose–response curves for the LY354740-induced initial inhibition of the fEPSP and for LTD.