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. 2002 Jun 1;22(11):4346–4356. doi: 10.1523/JNEUROSCI.22-11-04346.2002

Fig. 4.

Fig. 4.

Transduction pathways of mGlu2/3-LTD.A, mGlu2/3-LTD was not blocked in the absence of presynaptic activity. Summary of all of the experiments in which evoked synaptic stimulation was stopped during bath perfusion of LY354740 (200 nm) and 30 min after the washout. B, Summarized data showing that treatment with the adenylate cyclase activator forskolin (10 μm) inhibited the initial depression attributable to LY354740 and completely abolished mGlu-LTD.C, Summary of the effects the PKA inhibitor KT 5720 (1 μm) on basal synaptic transmission. D, Summary of all of the experiments in which the slices were preincubated at least 2 hr with the PKA inhibitor KT 5720 at 1 μm. In this condition, the initial depression of fEPSP by LY354740 was slightly decreased, and LTD at 60 min was totally prevented. E, Summary of the effects the PKA inhibitor H 89 (10 μm) on basal synaptic transmission.F, Summary of the experiments in which slices have been treated 20 min before, during, and 10 min after LY354740 application with the PKA inhibitor H 89 (10 μm). In this condition, the LTD induced by LY354740 was completely prevented at 60 min. *p < 0.05; **p < 0.01.