Fig. 5.

Fever and BAT thermogenesis induced by intra-MPO microinjection of PGE₂ are blocked by muscimol microinjection into the rRPa. a, b, Changes in T_BAT (a) and T_rec (b) after intra-MPO PGE₂ microinjection in rats microinjected with muscimol or saline into the caudal one-third of the rRPa. The sites of muscimol and saline microinjections are shown in c(Interaural −2.30 mm). Each value represents the mean ± SEM of three rats per group. The changes inT_BAT and T_recwere significantly different between muscimol- and saline-pretreated groups at least during the time period denoted by barswith asterisks (p < 0.05). The data shown in a and b are from the same animals. c, Composite drawing of the effect of muscimol or saline microinjections into ventral medullary regions on BAT thermogenesis stimulated by intra-MPO PGE₂microinjection. Each symbol represents the site of muscimol microinjection (filled circles andcrosses) or of saline microinjection (open circles) and corresponding change inT_BAT 40 min after PGE₂microinjection: ≤0.7°C (filled circles); ≥2.0°C (crosses and open circles).