Fig. 10.

GGF regulates Schwann cell death, but not proliferation, in the oculomotor nerve after NMDA administration. Schwann cell death was significantly reduced at E7.5 after NMDA treatment (1 mg) on E7 by either a single dose of GGF (5 μg) on E7, or two doses of GGF on E7 and E7.25 (A). GGF treatment did not significantly affect Schwann cell proliferation, as assessed by quantification of mitotic figures (B). Examples of mitotic figures of proliferating Schwann cells found in S-phase (C), metaphase (D), and anaphase (E) that were included in the mitotic counts in (B). All bars represent mean ± SEM for four to seven embryos.