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. 2002 Jun 1;22(11):4312–4320. doi: 10.1523/JNEUROSCI.22-11-04312.2002

Fig. 4.

Fig. 4.

Changes in properties of AMPA EPSCs caused by GluR2Q expression at hippocampal MF synapses. A,B, Representative AMPA EPSCs evoked by stimulation of MFs in uninfected (A) and SIN-EG-GluR2Q-infected (B) CA3 pyramidal cells. The EPSCs were recorded at various membrane potentials between −80 and +60 mV in 20 mV steps in the presence of 25 μmd-APV and 20 μm MK-801. To reduce polysynaptic excitation, 5 μm 2-chloroadenosine was also applied to the external solution. C, I–V relationship of AMPA EPSCs shown in A and B. The amplitudes of EPSCs normalized to those at −60 mV were plotted against the holding potential. The open and filled circlesindicate the data from uninfected cells and those infected with SIN-EG-GluR2Q, respectively. D, Histogram showing the distribution of RI values of AMPA EPSCs in SIN-EG-GluR2Q-infected cells (filled bars; n = 37) and uninfected cells (open bars; n = 31).