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. 2002 Mar 1;22(5):1513–1522. doi: 10.1523/JNEUROSCI.22-05-01513.2002

Fig. 3.

Fig. 3.

Immunohistochemical detection of oxytocin in the PVN (A–D) and in the SON (E–H) of C3H mice (A, E), Tg8 mice (B, F), α-MPT-treated Tg8 mice (C, G), and pCPA-treated Tg8 mice (D, H). Compared with C3H mice, OT-immunostained neurons are stained more strongly and are more numerous in Tg8 mice both in the PVN (B) and the SON (E). In α-MPT-treated Tg8 mice the intensity of OT immunoreactivity as well as the number of OT-immunopositive neurons declines in the PVN (C) and in the SON (G) compared with saline-control Tg8 mice (the same as B,F). Likewise, the treatment by pCPA in Tg8 mice is associated with a decrease in the number of OT-immunostained cell bodies and in the intensity of OT labeling both in the PVN (D) and the SON (H) compared with saline-control Tg8 mice. III, Third ventricle; OC, optic chiasma. Scale bar, 50 μm.