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. 2002 Mar 1;22(5):1942–1955. doi: 10.1523/JNEUROSCI.22-05-01942.2002

Fig. 11.

Fig. 11.

Simulated HSD as a result of stimulus-dependent decrement in release site number. In these models,Nsite decremented exponentially with each presynaptic action potential. During each simulation, nand Pves remained constant. InA, strong and weak synapses differed in the number of releasable vesicles. In B, strong and weak synapses differed in the initial Pves. InA, Pves was selected to achieve a Psite of 0.9 with 10 releasable vesicles; in B, Pves was selected to achieve a Psite of 0.25 and 0.75 for Pves Low andPves High, respectively, with 8 releasable vesicles. Average initial number of quanta released were: forA, 11.8 for two vesicles and 34.2 for nine vesicles; forB, 9.6 for Pves Low and 29.2 for Pves High. There was no significant difference in the time course of HSD between strong and weak synapses; [(A) repeated measure ANOVA testing interaction between vesicle number and trial number:F(14,145) = 1.5, p= 0.13. (B) repeated measure ANOVA testing interaction between Pves and trial number:F(14,145) = 1.3, p= 0.19]. Sampling interval was 0.25 msec.