Fig. 7.

THDOC enhanced single-channel open duration in α1β3δ GABA_A receptor single channels. Representative α1β3δ GABA_A receptor single-channel currents evoked by 1 mm GABA alone (A1), 1 mmGABA + 1 m THDOC (B1), and 1 mTHDOC alone (C1). A portion of the top trace in each panel is expanded in the trace directly beneath it (indicated by the open bar). Thetraces in A1 and B1 are from the same patch. The larger scale factor applies to the top traces. A2, B2, andC2 are the open duration histograms for all patches obtained for each condition (n = 3, 5, and 3 respectively). Superimposed lines are the fitted exponential functions describing the distributions.