Table 2.
Single-channel opening properties for α1β3δ GABAA receptors
Drug | τ1 | A1 | τ2 | A2 | τ3 | A3 | Mean | n |
---|---|---|---|---|---|---|---|---|
1 mm GABA | 0.31 ± 0.02 | 0.81 ± 0.06 | 1.02 ± 0.09 | 0.19 ± 0.06 | 0.444 ± 0.026 | 3 | ||
1 mm GABA + 1 μm THDOC | 0.357 ± 0.02 | 0.43 ± 0.04 | 1.822 ± 0.20 | 4.47 ± 0.03 | 5.94 ± 0.98 | 0.10 ± 0.03 | 1.52 ± 0.15 | 5 |
1 μm THDOC | 0.29 ± 0.02 | 0.72 ± 0.02 | 1.00 ± 0.23 | 0.24 ± 0.01 | 3.94 ± 1.70 | 0.04 ± 0.02 | 0.535 ± 0.054 | 3 |
The open duration histograms were fitted with multiple exponential functions, where τ is the time constant and A is the relative area.