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. 2002 Mar 1;22(5):1763–1771. doi: 10.1523/JNEUROSCI.22-05-01763.2002

Fig. 3.

Fig. 3.

Minocycline prevents MPTP-induced MAC-1 transcription. A, B, Ventral midbrain MAC-1 mRNA levels but not GFAP mRNA levels are increased by 24 hr after MPTP injection compared with those of saline- or minocycline-injected mice. Minocycline prevents MPTP-induced MAC-1 mRNA increases. MAC-1 and GFAP mRNA values are normalized with GAPDH. Values are mean ± SEM ratios (n = 5–7 mice per group).Saline, Saline-treated; Mc, minocycline-treated;MPTP, MPTP-treated; M + Mc, MPTP plus minocycline-treated. *p < 0.05, higher than both saline- and minocycline-injected control groups. **p < 0.05, lower than MPTP-injected group and not different from both control groups.