Fig. 4.
Aβinsol in Tg2576 mice is associated with impaired water maze performance. Brain Aβinsol40 and Aβinsol42 levels were determined by ELISA in a group of 4- to 6-month-old Tg2576 Tg+ mice (n = 28). When mice were segregated according to the presence (>5 pmol/gm of either Aβinsol40 or Aβinsol42) (n = 12) or absence of Aβinsol(n = 16), MPSs were significantly lower in mice with Aβinsol (t test; *p < 0.05). When mice were segregated by age (≤5 months, n = 13; or 6 months, n= 15), no significant differences were observed (data not shown).