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. 2002 Mar 1;22(5):1752–1762. doi: 10.1523/JNEUROSCI.22-05-01752.2002

Fig. 4.

Fig. 4.

Amyloid β-peptide enhances DNA damage in neurons under conditions of methyl donor deficiency. a, Comet assay analysis of nuclear DNA in neurons in a control culture and a culture that had been exposed for 8 hr in methionine/folic acid-deficient medium. b, DNA damage was quantified by comet analysis in hippocampal neurons after the indicated time periods of incubation in methionine/folic acid-deficient medium. Values are the mean and SD of determinations made in six cultures; *p < 0.01. c, DNA damage was quantified in neurons that had been exposed for 4 hr to the indicated treatments (5 μm Aβ1-42; 250 μm homocysteine). Values are the mean and SD (n = 6). **p < 0.01 compared with control. #p < 0.05,##p < 0.01 compared with Aβ alone (ANOVA with Scheffe's post hoc test). d, DNA damage was quantified by comet assay in hippocampal tissue samples from wild-type and APP mutant mice that had been maintained for 3 months on either the control diet or the methyl donor-deficient experimental diet. Values are the mean and SD (n = 8). *p < 0.01 compared with the value for APP mutant mice on the control diet and with WT mice on either diet.