Table 2:

GEMMA association results and genetic architecture statistics. The mean variance explained by all genotypes represents the mean of the posterior distribution of the proportion of phenotypic variance explained. The mean variance explained by large-effect SNPs represents the percentage of the total variance explained by only large-effect SNPs (e.g., large-effect SNPs associated with female age at first infection explained 36.5% of the 16.1% total variance explained by all SNPs, or approximately 5.9% of the total variance). Parentheses present 95% posterior credible intervals from the posterior distributions.

Sex	Phenotype	Mean Variance Explained By All Genotypes (%)	Median Variance Explained By All Genotypes (%)	Number large-effect SNPs	Mean Variance Explained By Large-effect SNPs (%)
Both	Age at infection	7.1 (0.3–21.6)	5.7	50.0 (0–270)	39.1 (0–96.2)
Both	Case/control	26.3 (8.8–50.2)	25.1	63.3 (0–269)	37.2 (0–96.1)
Both	Survival after infection	70.9 (27.6–99.9)	73.3	7.0 (1–34)	60.6 (26.2–97.3)
Female	Age at infection	16.1 (0.9 – 47.1)	13.1	38.1 (0 – 203)	36.5 (0 – 95.5)
Female	Case /control	61.4 (21.4 – 98.4)	61.3	56.1 (0 – 261)	38.3 (0 – 95.6)
Female	Survival after infection	80.1 (46.7 – 99.9)	82.4	4.8 (1 – 14)	76.5 (43.3 – 98.6)
Male	Age at infection	13.3 (0.4 – 42.5)	10.2	44.1 (0 – 246)	42.0 (0 – 96.4)
Male	Case /control	23.0 (1.4 – 64.9)	19.4	52.7 (0 – 261)	39.6 (0 – 96.3)
Male	Survival after infection	44.8 (1.1 – 99.6)	39.2	37.0 (0 – 196)	43.4 (0 – 96.6)