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. 2019 Jul 30;36(10):2227–2237. doi: 10.1093/molbev/msz097

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© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

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Fig. 5. — Structural model of dog Hb showing the net effect of β-chain substitutions G13S and L14M. (A) β-Chain of Tibetan mastiff/Tibetan wolf Hb, showing that the two substitutions result in the addition of two intra- and inter-helical hydrogen bonds (9-Ser: 13Ser and 15-Trp: 72-Ser, respectively). (B) β-Chain of domestic dog/gray wolf Hb, showing that 72-Ser forms an intrahelical hydrogen bond with 69Asn instead of the interhelical bond with 15Trp. Inset: structural model of tetrameric dog Hb with the β-chain subunit highlighted.