Table 4. Cox regression analysis for graft failure.
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (CI 95%) | P | HR (CI 95%) | P | |
| HLA incompatible | 0.63 (0.08–4.90) | 0.662 | 0.44 (0.02–8.21) | 0.581 |
| ABO incompatible | 0.60 (0.08–4.59) | 0.620 | 0.09 (0.01–1.50) | 0.093 |
| Age ≥60 y | 0.54 (0.07–4.14) | 0.551 | ||
| Gender, male | 1.31 (0.40–4.24) | 0.658 | ||
| Preemptive transplant | 1.48 (0.45–4.80) | 0.519 | ||
| Hypertension | 1.52 (0.34–6.86) | 0.587 | ||
| Diabetes mellitus | 0.99 (0.31–3.23) | 0.993 | ||
| Primary GN | 1.17 (0.38–3.58) | 0.782 | ||
| BMI ≥25 kg/m2 | 4.11 (1.38–12.25) | 0.011 | 1.48 (0.38–5.82) | 0.572 |
| HLA mismatches ≥5 | 3.13 (1.05–9.32) | 0.040 | 0.44 (0.11–1.84) | 0.262 |
| HLA-DR mismatches >1 | 2.67 (0.90–7.94) | 0.079 | ||
| Donor age ≥60 y | 4.38 (1.47–13.04) | 0.008 | 8.93 (1.73–46.00) | 0.009 |
| Donor gender, male | 0.58 (0.19–1.77) | 0.337 | ||
| Deceased donor KT | 1.16 (0.39–3.46) | 0.787 | ||
| BPAR | 142.87 (18.56–1099.83) | <0.001 | ||
| Active ABMR | 26.51 (8.90–78.94) | <0.001 | 16.24 (2.74–96.24) | 0.002 |
| Acute TCMR | 50.14 (13.77–182.58) | <0.001 | 30.84 (6.80–139.97) | <0.001 |
| 1 year eGFR <60 mL/min/1.73m2 | 8.61 (1.91–38.92) | 0.005 | 2.14 (0.30–15.57) | 0.451 |
| Re-transplant | 1.95 (0.25–15.01) | 0.524 | ||
Abbreviations: HR, hazard ratio; CI, confidence interval; GN, glomerulonephritis; BMI, body mass index; KT, kidney transplantation; BPAR, biopsy-proven acute rejection; ABMR, antibody-mediated rejection; TCMR, T-cell mediated rejection; eGFR, estimated glomerular filtration rate.