Skip to main content
. 2019 Sep 24;14(9):e0222228. doi: 10.1371/journal.pone.0222228

Fig 5. Clinical schedules and corresponding PK predicted activities for combinations of interest.

Fig 5

Dosing schedules for a 7-day treatment of oral etoposide paired with SP2509 and romidepsin. Plasma concentrations and estimated half-life for single-drug administration are derived from sources listed. Values in red indicate plasma concentrations comparable to experimental concentrations used. Values in boxes represent expected FA at given concentrations. Color represents amount of synergy expected. Gray boxes represent untested concentration combinations.