Fig 3. Hepatic mRNA levels and activity of enzymes involved in glycolysis after 3 weeks treatment with vehicle (control) or 1-triple TTA (1-tTTA) in rats.

(a) Insulin receptor mRNA level, (b) Slc2a2 mRNA level, (c) glucokinase mRNA level, (d) phosphofructokinase (Pfkl) mRNA level, (e) pyruvate kinase mRNA level, (f) pyruvate dehydrogenase (PDH) complex activity, (g) pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2) mRNA level, (h) pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4) mRNA level, (i) pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1) mRNA level. Gene expression levels were normalized to the house keeping gene Rplp0 and relative values are given. All values shown are means with standard deviation (n = 6–8). Statistically significant differences between means were determined using Students t-test, *p < 0.05 vs. control.