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. 2019 Sep 20;11:8589–8602. doi: 10.2147/CMAR.S186002

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© 2019 Zhang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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(A) miR-21 knockdown inhibited proliferation in the BGC-823 cells (^▁^⎂P<0.05). (B) miR-21 knockdown promoted apoptosis in the BGC-823 cells. (C) miR-21 knockdown inhibited proliferation in the SCG7901 cells (^⎂^∇P<0.05). (D) miR-21 knockdown promoted apoptosis in the SCG7901 cells. (E) miR-21 knockdown decreased the mRNA and protein levels of MMP-2, MMP-9, and bcl-2 and increased the level of Bax in the BGC-823 cells (^⋄^⋆^⢶^▁P<0.05; ^▁^⢶^⎂^△P<0.05). (F) miR-21 knockdown decreased the mRNA and protein levels of MMP-2, MMP-9, and bcl-2 and increased the level of Bax in the SGC-7901 cells (^△^♦^▁^⋄P<0.05; ^▁^⢶^⎂^△P<0.05).

Abbreviation: FITC, fluorescein isothiocyanate.