TABLE 1.
Recombinant-PyCSP-induced sterilizing immunity in BALB/c and C57BL/6 micea
| Mouse strain | Vaccine | % protection (no. of mice protected/no. challenged) |
|---|---|---|
| BALB/c | rPyCSP + ISA51 + mouse CpG ODN 1826 | 85.7 (42/49) |
| ISA51 + mouse CpG ODN 1826 | 0 (0/10) | |
| No vaccine | 0 (0/10) | |
| C57BL/6 | rPyCSP + ISA51 + mouse CpG ODN 1826 | 90 (9/10) |
| ISA51 + mouse CpG ODN 1826 | 0 (0/10) | |
| No vaccine | 0 (0/10) | |
a
Mice were immunized by three subcutaneous injections given at 3-week intervals. Two weeks after the last dose, mice were challenged intravenously with 100 P. yoelii 17XNL sporozoites.