Macrophages recruited to the site of ΔlipA mutant infection restrict S. aureus outgrowth. Outgrowth (log10 number of CFU per milliliter) of WT S. aureus after infection of F4/80+ cells isolated from mice at 72 h after intraperitoneal infection with the WT strain (n = 4), ΔlipA mutant (n = 4), or PBS (n = 4). Bars represent medians. P values were determined by 2-way ANOVA with Tukey’s posttest. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. The data shown are from one of at least three independent experiments.