FIG 11.

TLR3 plays a role in regulating Chlamydia-induced synthesis of biomarkers associated with iron sequestration, persistence, and autoimmunity during infection with C. trachomatis serovar D. WT and TLR3-deficient hOE cells were infected with C. trachomatis serovar D at an MOI of 10 IFU/cell for up to 72 h. Supernatants were collected from individual wells at the times indicated for multiplex ELISAs to measure the expression of sCD163 (A), lipocalin-2 (B), osteopontin (C), and pentraxin-3 (D). Statistically significant differences are shown by asterisks (*, P < 0.05; ***, P < 0.005; ****, P < 0.001). Data are representative of results from three independent experiments.