FIG 6.

TLR3 deficiency alters acute-phase inflammatory mediator synthesis during infection with C. trachomatis serovar D. WT and TLR3-deficient hOE cells were infected with C. trachomatis serovar D at an MOI of 10 IFU/cell for up to 72 h. Supernatants were collected from individual wells at the times indicated for multiplex ELISAs to measure the expression of IL-6 (A), IL-6Rα (B), sIL-6Rβ (gp130) (C), IL-8 (D), and CCL5 (E). Statistically significant differences are shown by asterisks (*, P < 0.05; **, P < 0.01; ***, P < 0.005; ****, P < 0.001). Data are representative of results from three independent experiments.