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TLR3 deficiency causes increased expression of type III IFNs. WT and TLR3-deficient hOE cells were infected with C. trachomatis L2 at an MOI of 10 IFU/cell for up to 30 h. Supernatants were collected from individual wells every 6 h for multiplex ELISAs to measure the expression of IL-29 (A) and IL-28A (B). Statistically significant differences are shown by asterisks (*, P < 0.05; **, P < 0.01; ***, P < 0.001). Data are representative of results from three independent experiments.
