FIG 9.

TLR3 regulates Chlamydia-induced expression of matrix metalloproteinases during genital tract infections with C. trachomatis. WT and TLR3-deficient hOE cells were infected with 10 IFU/cell of either C. trachomatis L2 (A to C) or C. trachomatis serovar D (D to F) for up to 72 h. Supernatants were collected from individual wells at the times indicated for multiplex ELISAs to measure the expression of MMP-1 (A and D), MMP-2 (B), MMP-3 (C and E), and MMP-10 (F). Statistically significant differences are shown by asterisks (*, P < 0.05; **, P < 0.01; ***, P < 0.005). Data are representative of results from three independent experiments.