FIG 2.

Hla expression during coinfection promotes animal death, despite acute antibiotic therapy. (A) Survival of C57BL/6 mice (n =10) infected with LAC or the Δhla mutant alone. (B) Survival of C57BL/6 mice (n ≥ 10 mice/group) superchallenged with LAC or the Δhla mutant on day 7 after PR8 virus infection. C57BL/6 mice were infected with PR8 and 7 days later were superchallenged with LAC or the Δhla mutant. (C to E) At 24 h after infection, the lungs were analyzed for bacterial (C) and viral (D) burdens and neutrophil numbers (E) in BALF (mean ± SD, n = 5). Starting at 4 h after MRSA infection, all mice were treated daily with the antibiotic vancomycin (Vanco) or linezolid (LZD). PMN, polymorphonuclear leukocyte. *, P < 0.05, log-rank test. The data shown are representative of those from two independent experiments.