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. Author manuscript; available in PMC: 2020 Sep 3.
Published in final edited form as: Curr Opin Genet Dev. 2019 Sep 3;55:106–113. doi: 10.1016/j.gde.2019.07.004

Figure 2:

Figure 2:

Actively transcribed genes interact around sites of concentrated transcriptional machinery

Highly specific transcriptional hubs form in (A) olfactory sensory neurons (OSNs) when olfactory receptor (OR) enhancers co-bound by Lhx2, EBF and Ldb1 from multiple chromosomes coalesce in cis and in trans to drive expression of the active OR allele. Large and stable transcriptional hubs form at (B) embryonic stem cell (ESC) super-enhancers bound by ESC transcription factors and co-activators Mediator and Brd4, which can converge with other super-enhancers tens of megabases away. These hubs are distinct from the transient, non-specific interactions (C) between actively transcribed genes around highly dynamic pol II clusters.