. Author manuscript; available in PMC: 2019 Nov 30.

Published in final edited form as: Lab Invest. 2019 May 31;99(10):1454–1469. doi: 10.1038/s41374-019-0269-y

Table 1.

Effects of missense and null Trp53 mutations on invasion depth of colon tumors

Mouse	A	SM	MP	SS	S	Total
AK	123 (93.9%)	1 (0.8%)	2 (1.5%)	4 (3.1%)	1 (0.8%)	131
AKP^270/+	163 (88.1%)	14 (7.6%)	5 (2.7%)	3 (1.6%)	0 (0.0%)	185
AKP^fl/fl	269 (73.9%)	59 (16.2%)	21 (5.8%)	13 (3.6%)	2 (0.5%)	364
AKP^270/fl	214 (63.1%)	86 (25.4%)	14 (4.1%)	15 (4.4%)	10 (2.9%)	339
Total	483	145	35	28	12	703

P-values for Fisher Exact Tests of the proportion of adenomas vs. adenocarcinomas (SM or worse)
	AKP^270/+	AKP^fl/fl	AKP^270/fl
AK	0.12	2.90E-07	7.20E-13
AKP^270/+		1.00E-04	3.10E-10
AKP^fl/fl			0.0026

A: adenoma; SM: submucosa; MP: muscularis propria; SS: subserosa; S: serosa