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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Exp Eye Res. 2019 Aug 23;187:107775. doi: 10.1016/j.exer.2019.107775

Fig. 4. The STAT3 signaling pathway is essential for CNV growth.

Fig. 4.

Western blotting demonstrates that the STAT3 pathway in the RPE-choroid complex is activated following the induction of choroidal neovascularization, while other FGF2-induced intracellular signaling pathways remain inactivate (A). Inhibition of STAT3 by the small molecule, Stattic, significantly suppressed choroidal sprouting 8 days post-explant dissection (n=6; 4.5 ± 0.9 vs 9.3 ± 0.8; *p<0.05; 2-way mixed ANOVA with Bonferroni’s multiple comparison test) (B). STAT3 inhibition also significantly suppressed CNV formation in vivo (n=7–8; 13496.7 ± 3202 μm2 vs. 44932.3 ± 13152.9 μm2, *p<0.05; two-tailed Student’s unpaired t-test) (C) Scale bar: 200 μm.