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. Author manuscript; available in PMC: 2019 Nov 10.
Published in final edited form as: Adv Drug Deliv Rev. 2018 Jul 6;145:57–72. doi: 10.1016/j.addr.2018.06.025

Fig. 5.

Fig. 5.

Schematic of phage T4 in vitro display system. The affinity-purified Soc-flised antigen (s) (A) are assembled on purified hoc−soc− T4 phage (B) by mixing the two at 4 °C for 45 min to generate the VIPs [138, 139]. The capsid can be displayed with one antigen (C) or a mixture of different antigens (D; shown in different colors). The same principle is used for the display of Hoc-fused antigens or targeting molecules [86, 92].